Comment by karmakaze

It's not that it only works on Nvidia cards, it's only allowed to work on Nvidia cards. A non-clean room implementation of CUDA for other hardware has been done but is a violation of EULA (of the thing that was reverse engineered), copyright on the driver binary interface, and often patents. Nvidia aggressively sends cease-and-desist letters and threatens lawsuits (successfully killed ZLUDA, threatened others). It's an artificial (in a technical sense moat).