I'm a tedious broken record about the fact that the base rate of most cancers means that extraordinarily-accurate-seeming screening tests have surprisingly untenable false positive rates. Like, a 99% accurate test for liver cancer might be almost worthless: because the base rate is so low, 99% of positives will be false.
And a false positive screening result is not innocuous: it incurs costs in a variety of different ways, including human health.
And a false positive screening result is not innocuous: it incurs costs in a variety of different ways, including human health.