Not really. Maybe in very specific applications of limit (fixed bet size) hold'em, but no limit texas hold'em, the most popular variant online, is very much unsolved, especially in multi-way pots. There are simply too many variables and strategies involved to calculate quickly enough on the fly. For games like omaha, which uses 4 hole cards, this is even harder.
Due to advancement of theory and study and popularity over the last ~20 years though, it's definitely much harder to be successful than it used to be.
Due to advancement of theory and study and popularity over the last ~20 years though, it's definitely much harder to be successful than it used to be.