OpenZL compressed SAM/BAM vs. CRAM is the interesting comparison. It would really test the flexibility of the framework. Can OpenZL reach the same level of compression, and how much effort does it take?
I would not expect much improvement in compressing nanopore data. If you have a useful model of the data, creating a custom compressor is not that difficult. It takes some effort, but those formats are popular enough that compressors using the known models should already exist.
I would not expect much improvement in compressing nanopore data. If you have a useful model of the data, creating a custom compressor is not that difficult. It takes some effort, but those formats are popular enough that compressors using the known models should already exist.