There is a theory that cholesterol elevates in response to circulating endotoxin (dead bacteria cell walls).
Lipoproteins can bind to the endotoxin, and clear it or at least stop immune cells from reacting to it.
This response increases LDL, but decreases the immune activity that would otherwise be created by letting the endotoxin circulate.
So LDL is a defense mechanism against the body's own response to circulating endotoxin as well as the endotoxin itself.
If true, that would explain the link between inflammation, LDL, and heart disease.
It would also imply that the circulating endotoxin is the thing to target.
I wonder where all the dead bacteria cell walls are coming from, probably where the dead bacteria are.
That, of course, is the gut.
I don't remember the original paper, but I found something that at least explains the theory here.
If true, that would explain the link between inflammation, LDL, and heart disease. It would also imply that the circulating endotoxin is the thing to target. I wonder where all the dead bacteria cell walls are coming from, probably where the dead bacteria are. That, of course, is the gut.
I don't remember the original paper, but I found something that at least explains the theory here.
https://www.sciencedirect.com/science/article/abs/pii/S01406...