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Comment by amluto

This sounds like a sort of plausible mechanism, but do you have any actual evidence that this occurs in real life? I admit that I’ve wondered whether the PrEP studies with lenacapavir actually measure what they thing they measure given that the same lenacapavir may prevent HIV from replicating enough to be detectable.

That being said, Wikipedia doesn’t really agree with your mechanism. See:

https://en.m.wikipedia.org/wiki/HIV_capsid_inhibition

It seems that the drug may inhibit disassembly of the capsid.

parent amluto 1 year ago

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