UConn coordinated a ton of work during the past two decades on mechanistic cell models. Mostly ODEs, PDEs, and stochastic ODEs. See The Virtual Cell at https://vcell.org.
It's interesting how high-throughput perturbation assays have led to data-driven whole cell models. But these are not yet good at making robust predictions.
Probably the future are hybrid neuro-symbolic models.
It's interesting how high-throughput perturbation assays have led to data-driven whole cell models. But these are not yet good at making robust predictions.
Probably the future are hybrid neuro-symbolic models.