My visualization library [1] is written in C and exposes a visualization API in C. It is packaged as a Python wheel using auto-generated ctypes bindings, which includes the shared library (so, dylib, or dll) and a few dependencies. This setup works very well, with no need to compile against each Python version. I only need to build it for the supported platforms, which is handled automatically by GitHub Actions. The library is designed to minimize the number of C calls, making the ctypes overhead negligible in practice.
[1] https://datoviz.org/