Comment by stasa

In a perfect world where you measure and control everything 100% CICO rules. However, in the real world, different types of food cause variation both on in and out. E.g. some foods promote feeling to satiety and some foods cause some people to overeat. Diet would also affect gut microbiome which affects hormones/mood etc... If you calculate CICO, then it will still be valid. But from the practical diet approach, CICO is oversimplification.