Comment by notfed

> Thesis: We should create a distro of Linux that runs Windows binaries by default via Wine.

On Debian you're one package away:

    sudo apt install wine-binfmt

Otherwise you're still pretty close:

    echo 'none /proc/sys/fs/binfmt_misc binfmt_misc defaults 0 0' >> /etc/fstab
    mount -a
    echo ':DOSWin:M::MZ::/usr/bin/wine:' > /proc/sys/fs/binfmt_misc/register