And there is so much still to uncover. Just the other day I was going through Neanderthal DNA during lunch and noticed that three of the four existing DNA samples show that they were carriers for the rs6467 form of Congenital Adrenal Hyperplasia (CAH) due to 21-Hydroxylase Deficiency.
Neanderthals were highly inbred and had low population numbers. Being a carrier of this form of CAH would have absolutely kept the population numbers low all by itself as getting two copies would have been nonviable. Further Neanderthals are most known for contributing to human specific DNA sets such as improved immune system. Here we have something that even in the non classic form is havoc with the HPA-Axis and give incredible evolutionary pressure to resolve, one way is to simply dramatically improve the immune system.
As far as I can tell this hasn't been written about before. Lots of stuff like this will be noticed and or figured out in the decades ahead.
Neanderthals were highly inbred and had low population numbers. Being a carrier of this form of CAH would have absolutely kept the population numbers low all by itself as getting two copies would have been nonviable. Further Neanderthals are most known for contributing to human specific DNA sets such as improved immune system. Here we have something that even in the non classic form is havoc with the HPA-Axis and give incredible evolutionary pressure to resolve, one way is to simply dramatically improve the immune system.
As far as I can tell this hasn't been written about before. Lots of stuff like this will be noticed and or figured out in the decades ahead.