> In children who have not already had dengue, the dengue vaccine increases the risk of hospitalization and severe illness if the child gets dengue after vaccination.
The mechanism is most likely that wild-type dengue has optimized itself a bit to infect better when covered with vaccinal antibodies (antibody-dependent enhancement)
> In children who have not already had dengue, the dengue vaccine increases the risk of hospitalization and severe illness if the child gets dengue after vaccination.
The mechanism is most likely that wild-type dengue has optimized itself a bit to infect better when covered with vaccinal antibodies (antibody-dependent enhancement)