Comment by FuriouslyAdrift

It also causes inactivation of vitamin B12 with long term use. This can cause demyelination and bone marrow suppression.

By the time you notice the peripheral neuropathy, it's probably too late. Note: to get to this point, you would be doing quite a lot at a time.

Be careful with nitrous and take your B12.

https://www.rch.org.au/clinicalguide/guideline_index/Nitrous...