It’s extremely relevant to the question, which is what the negative nature of the image has to tell us about the relative probabilities of the two hypotheses (miraculous hypothesis vs fraud hypothesis).
In my view, it is a big problem for the fraud hypothesis because you have to explain why and how it was done. At a time when the idea of a photo negative was entirely unknown, and when there are no other examples of negative images, or even any mention of the idea of making such images, why would the fraudsters seize on the idea of making their fraudulent image a negative? There is no record of anybody even recognising that it is a negative until the 19th century. So, it’s not at all what you would expect given the fraud hypothesis. You would expect a straightforward image.
In my view, it is a big problem for the fraud hypothesis because you have to explain why and how it was done. At a time when the idea of a photo negative was entirely unknown, and when there are no other examples of negative images, or even any mention of the idea of making such images, why would the fraudsters seize on the idea of making their fraudulent image a negative? There is no record of anybody even recognising that it is a negative until the 19th century. So, it’s not at all what you would expect given the fraud hypothesis. You would expect a straightforward image.