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Comment by FollowingTheDao

IMHO, it is all about lowering oxidative stress. Eating creates oxidative stress in the body because to eat means to create ATP and that means electrons are increased in the mitochondria. More electrons = more oxidative stress in the form of superoxides.

I will say that Calorie Restriction with Optimal Nutrition (or CRON) is the healthiest diet but should be geared towards ones heritage or genetics (which is why I think all of the studies on humans have such variable and confounding outcomes.).

http://optimal.org/voss/cron_overview.html

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