Comment by CraftingLinks

Mice are very different from humans in that they are prey and we are predator. The reason that this is significant is that evolutionary, mice life history is optimalized for more offspring and shorter life, whereas predators are optimized for long life and few offspring. We know since 1993 with the discovery of the daf-2 gene (a nematode insulin receptor) that genetics can drastically affect longevity. However, and this is my own professional hypothesis, in humans we have tuned the genetic dial to max lifespan, whereas in mice and worms it is not. In these animals there is plenty of flexibility left to tune up lifespan, not so in humans. We may see moderate effects due to increased health though.