> I confirm that oncology knowledge has grown dramatically. The total length of NCCN Guidelines, a “complete library” of cancer guidelines (NCCN, 2023b), has grown from 1,129 pages in 2002 to 5,825 pages in 2020. This growth in guideline length appears closely tied to growth in the scientific literature about how to manage cancer. This growth in guideline length also occurs in a period with large increases in the number of available therapies: the total number of approved cancer drugs rose from 90 in 2002 to 243 in 2020.
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