APE works through cunning trickery that might get patched out any day now (and in OpenBSD, it has been).
Most people producing cross-platform software don't want a single executable that runs on every platform, they want a single codebase that works correctly on each platform they support.
With that in mind that respect, languages like go letting you cross compile for all your targets (provided you avoid CGO) is delightful... but the 3-ways-executable magic trick of APE, while really clever, doesn't inspire confidence it'll work forever, and for the most part it doesn't gain you anything. Each platform has their own packaging/signing requirements. You might as well compile a different target for each platform.
Most people producing cross-platform software don't want a single executable that runs on every platform, they want a single codebase that works correctly on each platform they support.
With that in mind that respect, languages like go letting you cross compile for all your targets (provided you avoid CGO) is delightful... but the 3-ways-executable magic trick of APE, while really clever, doesn't inspire confidence it'll work forever, and for the most part it doesn't gain you anything. Each platform has their own packaging/signing requirements. You might as well compile a different target for each platform.