> Purified recombinant Reelin was injected bilaterally into the ventricles of wild-type mice. We demonstrate that a single in vivo injection of Reelin increased activation of adaptor protein Disabled-1 and cAMP-response element binding protein after 15 min. These changes correlated with increased dendritic spine density, increased hippocampal CA1 long-term potentiation (LTP), and enhanced performance in associative and spatial learning and memory.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166788/
Published 2011. It's been a while... I wonder what it would take to reach human trials.