> matching less than 60% of the sequence of the most closely related fluorescent protein
> When the researchers made around 100 of the resulting designs, several were as bright as natural GFPs, which are still vastly dimmer than lab-engineered variants.
So they didn't come up with better functionality, unlike what some commentators imply. They basically introduced a bunch of mutations while preserving the overall function.
> When the researchers made around 100 of the resulting designs, several were as bright as natural GFPs, which are still vastly dimmer than lab-engineered variants.
So they didn't come up with better functionality, unlike what some commentators imply. They basically introduced a bunch of mutations while preserving the overall function.
Relevant: https://en.wikipedia.org/wiki/Conservative_replacement