Horizon 5 did not work for me and many others on Windows 10 LTSC Version 1809 when it was the de-facto latest LTSC available. I'm not sure what feature was missing but it was working just fine with the latest Windows 10 Pro version available at that time. Of course things might differ now but I still wouldn't say that compatibility is big on LTSC when there's a high chance that a new game might be missing essential features which only get added in the next LTSC version.
See also: https://www.reddit.com/r/Windows10LTSC/wiki/incompatibility