Some of the rare-ish side effects we've seen are genuinely concerning (gastroparesis is not fun!), but I didn't realize until recently that we actually have a lot of data about those side effects because GLP-1 agonists have on the market for a few decades now. And the safety profile is pretty good overall.
Granted, the specific formulations we're seeing spike in popularity are newer, and they've only recently been approved for weight loss rather than things like diabetes, but it's not a totally newfangled technology.
For comparison, some of the older-gen GLP-1 agonists have been around about as long as Humira has, and significantly longer than a lot of the drugs you see advertised on TV/video ads nowadays.
Granted, the specific formulations we're seeing spike in popularity are newer, and they've only recently been approved for weight loss rather than things like diabetes, but it's not a totally newfangled technology.
For comparison, some of the older-gen GLP-1 agonists have been around about as long as Humira has, and significantly longer than a lot of the drugs you see advertised on TV/video ads nowadays.