Hardware QA is sometimes hit and miss, but Roccat mice have a shift feature that is implemented in firmware. The same goes for their macros: their mouse emulates a keyboard at the hardware level. That way it Just Werks and you don't need some cringey gamer-themed spyware always running in the background just to make full use of it, like you do for many features with Logitech mice. My go-to atm is the Kone XP, which doesn't have as many side buttons as the Logitech G6xx mice. They do make an 'MMO mouse' with many many buttons like that called the 'Nyth'.
Unfortunately their configuration software hasn't supported macOS for a long time, but you can configure your device on a Windows VM via USB passthrough, which is what I do. Alternatively, there are also several reverse-engineered tools for configuring Roccat mice, including libratbag (and the older roccat-tools) for Linux and roccat-iokit for macOS, if you'd be interested in either choosing a model according to what's supported there or adding support for the Nyth.
Unfortunately their configuration software hasn't supported macOS for a long time, but you can configure your device on a Windows VM via USB passthrough, which is what I do. Alternatively, there are also several reverse-engineered tools for configuring Roccat mice, including libratbag (and the older roccat-tools) for Linux and roccat-iokit for macOS, if you'd be interested in either choosing a model according to what's supported there or adding support for the Nyth.