I have a keyboard that's "missing" essential keys, but I have a special key that I can press with my thumb that changes that every single key does (it's called a Layer). So I never need to move my wrist to press the arrow keys: just hold the thumb button and press hjkl. Page up is layer+t, page down is layer+g. And so on. It's great, my wrists thank me. I can even program a macro that will trigger an OS shortcut that will send a packet to my Smart Coffee Grinder or tell Alexa to call 911. Or have the F479001600 key you mentioned.
There are a bunch of keyboards with this functionality. I personally use a Dygma Raise.
There are a bunch of keyboards with this functionality. I personally use a Dygma Raise.