> The knowledge about toxicity from hypervitaminosis D in terms of dosage and duration is limited. Because of the high heterogeneity in reported amounts of vitamin D intoxication cases, it is not possible to calculate a reliable mean value that will invariably induce toxic effects. The highest daily dose hitherto reported in the literature is about 2,000,000 UI/day that has led to intoxication in a couple of months
> Moreover, the highest cumulative dose (657,000,000 UI) leading to toxicity was obtained after 36 months of treatment with cholecalciferol 600,000 UI/day
> Moreover, the highest cumulative dose (657,000,000 UI) leading to toxicity was obtained after 36 months of treatment with cholecalciferol 600,000 UI/day