I overlaid bluefin-dx [1], the developer oriented build by ublue, over my Fedora Silverblue system and it's been pretty great so far. Feels a little bloated for my taste, which is why I started my own fork [2]. The ability to change things up in a layered way (basically a Dockerfile) without risking breaking anything at the host level is really nice!
1. https://universal-blue.discourse.group/docs?topic=39 2. https://github.com/sqwxl/sophon