I just filed https://chrome-please-fix-your-audio.xyz the other day for chrome bug #327472528 - apparently all audio output is noise-reduced from audio input in Chrome - even when using headphones and when explicitly disabling this feature in the Web Audio API. It basically means you can't make any music app where you sing along with a background track, among other obvious use cases for microphones.
https://issues.chromium.org/issues/327472528