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Comment by COGlory

Muyuan Chen is one of (maybe the?) primary developer of the sub-tomogram averaging portion of the EMAN2 software package (linked below in another comment). Typically what you do is take a 3D tomogram (think like a scan) using a microscope, but it's extremely noisy. Then you go through and extract all the particles that are identical, but in different orientations, in the tomogram. So if the same protein is there multiple times, you can align them to each other, and average them together to increase the signal. Then you clone back in the higher signal averaged volume at the position and orientation that you found them in originally.

The one-line command to go from EMAN2 coordinates to Unreal Engine 5 is kind of crazy.

As usual on these (rare) threads, I'm happy to answer any questions about structural biology or cryo-EM.

parent COGlory 2 years ago

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