It turns out the dissertation is not quite published yet, but this paper [1] will be a part of it. Sam and I were in the same lab and his work has evolved to focus even more on AI-guided protein design. Perhaps the quote from the abstract that made the connection for me to this post:
> We applied the protein G B1 domain (GB1) models to design a sequence that binds to immunoglobulin G with substantially higher affinity than wild-type GB1.
> We applied the protein G B1 domain (GB1) models to design a sequence that binds to immunoglobulin G with substantially higher affinity than wild-type GB1.
[1] https://www.pnas.org/doi/pdf/10.1073/pnas.2104878118?downloa...