Ask HN: When to Start a Business?

I am aware that this is a very comprehensive question. It includes individuals own circumstances, experience, country, and macroeconomic situation. In my life, I have tried to start a business or frequently had the urge to start one. But, retrospectively, when I look at them, I see many reasons why I shouldn't have done it. Moreover, these created a huge amount of opportunity cost. I think I am more inclined to be impatient regarding this topic. My question is more specifically: what are the heuristics I can use to understand that this is the right time for me to start a business that does not create huge opportunity costs and is not an impulse that is the result of my impatience?