I’ve worked in a lab of one of the original folks working on genetic logic gates, and honestly, no they don’t really work very well at all.
I think a lot of computer scientists assume that their model of the world (binary logic) is the most abstracted version possible, and you can drill down other information carrying systems to that level, and then use that knowledge to build reliable systems.
Biology does not work that way. Its fundamental abstraction is different (mostly one of massive interconnectedness). Engineering logic gates and the like, mostly, doesn’t actually allow you to build better genetic circuits.
I think a lot of computer scientists assume that their model of the world (binary logic) is the most abstracted version possible, and you can drill down other information carrying systems to that level, and then use that knowledge to build reliable systems.
Biology does not work that way. Its fundamental abstraction is different (mostly one of massive interconnectedness). Engineering logic gates and the like, mostly, doesn’t actually allow you to build better genetic circuits.