The only roadblock I’ve found has been the webserial API, which enables users to flash ESP32/8266 or other devices from webpages. It’s super handy for flashing WLED or ESPHome to devices because you don’t have to install any extra software. As far as I know, it has been marked as a “wontfix” in the Firefox bugtracker as they consider it a harmful feature [0]
[0]: https://github.com/mozilla/standards-positions/issues/336