This may be a somewhat uninformed opinion, but I think CPython is just straight up not particularly good software. There are a million and one optimizations that other major scripting runtimes (V8, LuaJIT, PyPy, Ruby YJit etc.) have had for years that CPython is lacking. This is by design though. CPython has never been focused on performance, that's why it's not even JIT. It optimizes for simplicity and easy interoperability with C.
The problem is that because Python is such a ubiquitous language, CPython gets more attention than it deserves. People see it as an archetypical implementation of a scripting language. We get blogposts like this examining its inner workings, discussions about how its performance could be improved, comparisons of its speed vs. compiled languages, and tutorials on how to optimize code to run faster in it. I feel like all of this effort would be better spent on discussions about runtimes that actually try to be fast.
The problem is that because Python is such a ubiquitous language, CPython gets more attention than it deserves. People see it as an archetypical implementation of a scripting language. We get blogposts like this examining its inner workings, discussions about how its performance could be improved, comparisons of its speed vs. compiled languages, and tutorials on how to optimize code to run faster in it. I feel like all of this effort would be better spent on discussions about runtimes that actually try to be fast.