This is why the reductionist argument of "your brain is reducible to a computer with inputs/outputs like any other, all we have to do is reimplement it" of AGI proponents always fell flat to me.
It's now becoming clear that we can't just take the brain in isolation, treating the spinal nerve like a PCI-E lane - the gut has to come with it. And if the gut comes with it, all the other organs (skin top of the list) probably do as well.
Now to model a human brain, you need to model an entire human, along with all the complexity of the microbiota, interactions of the organs with the environment... it all just falls apart.
It's now becoming clear that we can't just take the brain in isolation, treating the spinal nerve like a PCI-E lane - the gut has to come with it. And if the gut comes with it, all the other organs (skin top of the list) probably do as well.
Now to model a human brain, you need to model an entire human, along with all the complexity of the microbiota, interactions of the organs with the environment... it all just falls apart.