Acetaminophen has a narrow therapeutic index and can cause severe and irreversible liver injury in doses around 10 g. A single tablet usually contains 500 mg, but because it's a component of so many other "combo" cold meds, including some syrups, it's easy for people to overdose while mixing OTC products to get over a flu.
Aspirin has a lower standard dose (325 mg), higher LD50 (probably around 20-25 g), and is generally safer. It has fallen out of favor because it's known to cause an exceedingly rare but deadly syndrome in a tiny percentage of children, and because it can have gastroenterological side effects.
Ibuprofen is probably the safest option? I'm sure it can be overdosed, but it almost never happens, whereas acetaminophen results in tons of hospitalizations every year.
Aspirin has a lower standard dose (325 mg), higher LD50 (probably around 20-25 g), and is generally safer. It has fallen out of favor because it's known to cause an exceedingly rare but deadly syndrome in a tiny percentage of children, and because it can have gastroenterological side effects.
Ibuprofen is probably the safest option? I'm sure it can be overdosed, but it almost never happens, whereas acetaminophen results in tons of hospitalizations every year.