For fairly simple organisms we have 'cold booted' DNA and swapped a cells DNA with artificial DNA from a closely related organism and it still worked. So, while humans have a lot of Genetic information I suspect you could get it to work if your willing to accept fairly low success changes.
As to read errors that effectively just a 'mutation' which are generally fairly harmless. If you stay below say 1,000 mutations, which would still take vary high accuracy, you have not significantly reduced your chances for success.
As to read errors that effectively just a 'mutation' which are generally fairly harmless. If you stay below say 1,000 mutations, which would still take vary high accuracy, you have not significantly reduced your chances for success.