Comment by gzer0

If you go to Options > Filter Lists > Annoyances and check mark the following items:

  "AdGuard – Annoyances"
  "EasyList – Annoyances"
  "uBlock filters – Annoyances"

You will get rid of 99.9% of website annoyances without affecting any main functionality of websites.

I've been doing this on every fresh install of Chrome for years. Works wonders.