There was a version of streptococcus mutans developed that didn’t produce tons of lactic acid and would have pretty much ended tooth decay back in 2000. Iirc, it was built to outcompete the regular bacteria too. As far as I can tell there’s been no progress in commercializing this-—I assume because of the cost and complexity of FDA approval.
E.g., https://pubmed.ncbi.nlm.nih.gov/12369203/