Comment by tyingq

Python running well in WASM requires WASM to be more like a virtual machine (as in JVM, not KVM) and less like ASM. WASM is headed that way, with things like GC. But then you also need direct DOM integration. And even if you have both of those working well, Python's runtime and stdlib are pretty large, and if everyone picks a different version of Python they want to run, there's no economy of scale. Couple that with browsers all killing off the advantage of shared libraries in a CDN via cache partitions. It feels like the road to all of that working reasonably well in all situations is pretty long.