Comment by danbruc

I am aware that I know next to nothing about the topic and that I am ignorant of countless complications. With that said, your pancreas also does not know that you plan to work out, at least I would assume so. So what is the crucial difference between a pancreas and insulin injections? That the response is delayed because the injection is not into the blood stream or does the pancreas also have better sensors to figure out how much insulin to release, or maybe even release things other than insulin? If it is the former, what obstacle is there for injecting into the blood stream? The infection risk of having a permanently open port into the circulatory system? If so, is there a similarly effective way to deliver insulin that is not into the blood stream and with less risks? Or could you have some kind of membrane in the port that only allows insulin to pass through but that is impermeable for pathogens? Or would that get clogged immediately?