What exactly are you trying to run? The ideal stack really depends on your app, it's not a one size fits all question. Often there is a tradeoff between complexity and power, for example. Or ease of use vs ease of migration.
It might also be a good idea to investigate some of the existing edtech offerings (canvas, moodle, blackboard etc.) and see if it makes sense to either use a similar stack (if you want to run alongside them) or do something totally different (if you want heavy AJAX interactions, for example).
It might also be a good idea to investigate some of the existing edtech offerings (canvas, moodle, blackboard etc.) and see if it makes sense to either use a similar stack (if you want to run alongside them) or do something totally different (if you want heavy AJAX interactions, for example).