Comment by WillPostForFood

One difference between espresso and coffee made with a paper filter is that there is more cholesterol in espresso. Espresso extracts more from the bean because it is done under pressure, and the paper filter collects some the cholesterol. There is some evidence of a connection between high cholesterol and Alzheimers, so you might expect espresso to be worse, but it doesn't seem that well understood. Maybe the cholesterols in coffee beans act differently.