At Trail of Bits, we've been working on this type of IR for C and C++ code [1]. We operate as a kind of Clang middle end, taking in a Clang AST, and spitting LLVM IR that is Clang-compatible out the other end. In this middle area, we progressively lower from a high-level MLIR dialect down to LLVM.
[1] https://github.com/trailofbits/vast