I was lucky enough to do some programming work, very many years ago, in the 1990s, in the laboratory of Ralph Siegel (https://en.wikipedia.org/wiki/Ralph_Siegel_(scientist)), who among other things worked on this type of worm connectome models. He used the Hodgkin-Huxley equations to simulate neuron responses on the connectome. The Hodkin-Huxley model, as someone explained to me, is kind of like modeling a human leg as three rigid blocks connected by hinges - it's enough to be useful in many models, but of course it's not a full description. Also, it may not the right model for worm neurons, because worm neurons are non-spiking, and the HH equations describe neurons that produce trains of spikes; they exist in more complicated nervous systems. The HH equations are used in simulations because it's the mathematical model we have, and it seems that they're still used by the OpenWorm project. (I am not very sure about properties of worm neurons, I heard about this a long time ago and the information may be out of date).
I think it's great that this work is still going on, it may produce insights about functioning of nervous systems. But the difficulties are fierce, and we're making very slow and difficult progress in an immense unknown area.
I think it's great that this work is still going on, it may produce insights about functioning of nervous systems. But the difficulties are fierce, and we're making very slow and difficult progress in an immense unknown area.