Comment by krob

CI/CO is ideal circumstances, just like falling from the sky, computing how long it takes to hit the ground is not as simple as it's 9.8ms/s^2*m, you have to build a differential equation that accounts for all the various force factors involved. Our biology are those various force factors playing on the rate of incorporation of the energy and how the system which consumes energy may alter pathways, and this is where we run into permutations of the metabolism that are not accounted for by CI/CO. We know that people with metabolic syndrome and insulin resistance cannot loose weight because their hyper sensitive to any amount of sugar, so insulin causes them to constantly store energy, but some people who eat a lot of calories get a massive energy boost like they almost got some caffeine in their system. Our biology has millions of biological permutations that ideal systems cannot account for.