Anecdotally, I gave Dvorak a try and became somewhat proficient, but ultimately reverted back to QWERTY for one reason: keyboard shortcuts! Control-C|V|Z are all transformed into either two-handed shortcuts or right-handed shortcuts. In either case, I can't copy/paste while selecting text with the mouse (since I'm right-handed).
I now use Colemak (https://colemak.com/) which doesn't have this issue and I'm quite happy with!
I now use Colemak (https://colemak.com/) which doesn't have this issue and I'm quite happy with!