Comment by jamesash

An early stage lab has a lot in common with a startup. The PI is given seed money to validate an ambitious idea and has limited time and resources to do it. The work is extremely labor intensive and in the early stages the PI will be in the trenches with the early employees working in the lab and setting an example for them to follow. Fast failure and pivots are extremely common. Furthermore, at any time the research idea could get scooped by another hard-working research lab, resulting in publication in a lower-tier journal. The PI must get early results that can be used to obtain further research grants. A good PI in this situation will set expectations accordingly that 60+ hour weeks will be required and hopefully those who are not willing to do so will self-deselect. From their perspective I completely not understand not wanting to invest $50k/year of their startup funds in a graduate student who is not putting in the necessary time to succeed. The prospective graduate student's maximum power is at the time when they are choosing a research advisor. Choose wisely, and remember you are always free to choose not to go if you don't see a good situation. I advise that people think long and hard about whether or not they truly want to do graduate school. There are far better ways to spend your 20's than in a lab. I had two great experiences in "intense" labs in my field (organic chemistry) after a very poor experience with a prestigious but absentee graduate advisor in another field - but it is definitely not for everyone.