I believe a framework like Bootstrap might be a faster approach at the beginning (honestly, it's a fair approach for the whole lifecycle of a project). You get all the building blocks to get a consistent UI working fairly quick with little to no CSS knowledge. Some times removing the unnecessary flexibility may be a boost to get things out there.
But, at the end of day, the best option will be the one you're most comfortable with.
But, at the end of day, the best option will be the one you're most comfortable with.