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Comment by theaiquestion

~15/20ug is the dose an experienced person would percievably be able to notice, so microdosing is below this.

75ug is the lower end of the recreational scale. I first ever started with ~50ug (which honestly I'd recommend for beginners) and I had antidepressents in my system so it's effect is dulled a bit - and that was a giggly, eyes-full-of-wonder, oversaturated, and slight motion inpainting, wonderful experience. There was no way anyone mistakes that for being sober.

That said the come-up at any dose and any experience level is hilarious because everyone is always like "is it hitting yet?" as it progressively becomes more intense.

tl;dr - placebo could fool even some experienced users if they know they're being given a really low dose. The treatment group would absolutely know no matter how much experience you have.

https://psychonautwiki.org/wiki/LSD

EDIT: Sidenote, safety first friends. Always use two different reagents to test, and always have a plan to control anxiety in case of bad trips.

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