It seems to me like the biggest concern (at least this is the case for me (a layman) and my girlfriend (a PhD candidate studying Chemical Biology)) for us is that building infrastructure that uses PFA-based materials increases the chances of them ending up in water or food.
For example, I used to drink tons of unflavored, purified carbonated water (aka "Seltzer Water"). I thought this is likely not very unhealthy since it's literally just pure water + carbon dioxide dissolved in it. It made me drink tons of more water (we're talking significantly more water than I would normally drink) so I thought it's a net benefit. But some evidence came out [1] that common seltzer brands have detectable amount of PFA in them. This may be because (1) PFAs are in water sources, (2) PFAs are in the plumbing systems of these companies' factories, (3) something else. Since we don't know how much PFA is too much, we've been a lot more meek about drinking seltzer water. To be honest, I still do drink it, but a lot less so. I mostly drink tap water, and in the area I live in (Boston, MA), there is no PFA detection, or it's very low.
For example, I used to drink tons of unflavored, purified carbonated water (aka "Seltzer Water"). I thought this is likely not very unhealthy since it's literally just pure water + carbon dioxide dissolved in it. It made me drink tons of more water (we're talking significantly more water than I would normally drink) so I thought it's a net benefit. But some evidence came out [1] that common seltzer brands have detectable amount of PFA in them. This may be because (1) PFAs are in water sources, (2) PFAs are in the plumbing systems of these companies' factories, (3) something else. Since we don't know how much PFA is too much, we've been a lot more meek about drinking seltzer water. To be honest, I still do drink it, but a lot less so. I mostly drink tap water, and in the area I live in (Boston, MA), there is no PFA detection, or it's very low.
[1] https://www.cbsnews.com/news/pfas-chemicals-in-sparkling-wat...